PRELIMINARY EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF DITHIOCARBAMATE RESINS BASED ON GMA-EDGMA COPOLYMERS

  • Luciana Costa Centro Universitário Estadual da Zona Oeste
  • Helena M.A. Castro, Sr. UEZO
  • Raphaela S. Franco, Sr. UEZO
  • Roberta Trovão Santos, MsC UEZO
  • Ezaine C.C. Torquato, MsC UEZO
  • Mônica R.C. Marques, Dr. UEZO

Resumo

In this work we report the development of a new strategy for the preparation of dithiocarbamate resins based on glycidyl methacrylate-ethylene glycol dimethacrylate (GMA-EDGMA) copolymers. The methodology for introduction of the dithiocarbamate moieties on these copolymers was based on reaction with ethylenediamine, triethylenetetramine, tetraethylenepentamine and then reaction with carbon disulfide under alkaline medium. The antimicrobial activity of these products was evaluated employing inhibition halo tests against Escherichia coli (Gram-negative bacteria) and Staphylococcus aureus (Gram-positive bacteria). Data of N2 adsorption indicated that GMA-EDGMA copolymer containg a mesoporous structure. Data of FT-IR indicated that reaction of copolymers with diamines occurred in a reazoable proportion however the reaction of the aminated derived with CS2 occurred in lower proportion. Only the copolymer containing dithiocarbamate groups prepared by reaction with diethyltriamine and carbon disulfide showed halo of inhibition against E. Coli and S. Aureus bacteria.

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Unidade Universitária de Farmácia, Centro Setorial de Ciências Biológicas e da Saúde

Publicado
2021-07-03
Como Citar
COSTA, Luciana et al. PRELIMINARY EVALUATION OF THE ANTIMICROBIAL ACTIVITY OF DITHIOCARBAMATE RESINS BASED ON GMA-EDGMA COPOLYMERS. Acta Scientiae et Technicae, [S.l.], v. 9, n. 1, jul. 2021. ISSN 2317-8957. Disponível em: <http://www.uezo.rj.gov.br/ojs/index.php/ast/article/view/324>. Acesso em: 03 jul. 2022. doi: https://doi.org/10.17648/uezo-ast-v9i1.324.
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Artigos